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Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which might be made up of several active ingredient, which may make them more potent and safer. Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that by right now there aren't any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug may also raise hypertension and heart rate, and must not be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must not used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. The most common adverse reactions reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.